https://doi.org/10.4081/ltj.2024.401

Effectiveness of photobiomodulation and resistive exercise on cartilage tissue in osteoarthritic rats

Vol. 31 No. 2 (2024)
Submitted: 3 May 2024
Accepted: 4 July 2024
Published: 5 August 2024
Photobiomodulation, articular cartilage, knee osteoarthritis, physical exercises
Abstract Views: 1214
PDF: 186
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Authors

Luiz Henrique Gomes Santos
Federal University of São Carlos, Department of Physiotherapy, São Carlos; University Center of Educational Foundation Guaxupé - UNIFEG, Guaxupe, Brazil.
Lívia Assis
Scientific Institute and Technological Department - University Brazil (UB), São Paulo-Itaquera, Brazil.
Carla Roberta Tim
Scientific Institute and Technological Department - University Brazil (UB), São Paulo-Itaquera, Brazil.
Thatiane Izabele Ribeiro Santos
https://orcid.org/0000-0002-5418-5624
Department of Biosciences, Federal University of São Paulo, Santos, Brazil.
Cintia Cristina Santi Martignago
https://orcid.org/0000-0003-3980-6354
Department of Biosciences, Federal University of São Paulo, Santos, Brazil.
Mirian Bonifácio Silva
Department of Biosciences, Federal University of São Paulo, Santos, Brazil.
Fernando Vasilceac
Federal University of São Carlos, Department of Gerontology, São Carlos, Brazil.
Mariane Santos Trevisan
Federal University of São Carlos, Department of Gerontology, São Carlos, Brazil.
Daniel Araki Ribeiro
Department of Biosciences, Federal University of São Paulo, Santos, Brazil.
Lillian Cristina Lopes Cunha
Federal University of São Carlos, Department of Gerontology, São Carlos, Brazil.
Nivaldo Antonio Parizotto
Federal University of São Carlos, Department of Physiotherapy, São Carlos, Brazil.
Ana Claudia Rennó
acmr_ft@yahoo.com.br
Department of Biosciences, Federal University of São Paulo, Santos, Brazil.

The aim of the present study was to investigate the association of a resistive training and Photobiomodulation (PBM) on cartilage tissue in an experimental model of knee Osteoarthritis (OA). Forty male Wistar rats (weigh, ± 150g) were distributed into 4 groups. Treatments were performed for 8 weeks (3 sessions per week). The specimens were evaluated by histology, OARSI, morphometric and immunohistochemistry analysis. The results showed that the interventions were able to modulate the degenerative process reacted to OA. Exercised animals (with or without PBM) demonstrated lower values for OARSI and lower expression of IL-1β, caspase-3, MMP-13. Furthermore, animals treated with the associated treatments presented significantly decrease in the density of chondrocytes. Resistive exercise training modulated the morphological alterations and inflammatory process related to the OA progression. However, PBM isolated have not produce extra effects on the variables evaluated.

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How to Cite

Gomes Santos, L. H., Assis, L., Tim, C. R., Ribeiro Santos, T. I., Santi Martignago, C. C., Bonifácio Silva, M., … Rennó, A. C. (2024). Effectiveness of photobiomodulation and resistive exercise on cartilage tissue in osteoarthritic rats. Laser Therapy, 31(2). https://doi.org/10.4081/ltj.2024.401
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