Low-level laser therapy as an adjuvant in the treatment of erythema multiforme of the oral mucosa: a case report

Submitted: 16 January 2024
Accepted: 5 February 2024
Published: 5 March 2024
Abstract Views: 584
PDF: 137
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Erythema multiforme is an autoimmune condition that can affect the skin and mucosa. Oral lesions initially present with edema and progress to superficial erosions with pseudomembrane formation. The most recommended treatment is the use of corticosteroids; however, low-level laser therapy can be effective in the treatment of erythema multiforme. We report a case of erythema multiforme in the oral mucosa treated with low-level laser therapy. A 73-year-old woman using alendronate for osteoporosis, losartan, and puran T4 with extensive ulcers on the upper and lower lips. The clinical diagnosis was erythema multiforme. The proposed treatment was 0.05% clobetasol propionate in gel, 3 times a day, and seven sessions of low-level laser therapy on alternate days. Low-level laser therapy significantly improved the erythema multiforme of the oral mucosa, offering the patient a non-invasive approach with no side effects.

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Citations

Trayes KP, Love G, Studdiford JS. Erythema Multiforme: Recognition and Management. Am Fam Physician 2019;100:82-8.
Kempton J, Wright JM, Kerins C, Hale D. Misdiagnosis of erythema multiforme: a literature review and case report. Pediatr Dent 2012;34:337-42.
Samim F, Auluck A, Zed C, Williams PM. Erythema multiforme: a review of epidemiology, pathogenesis, clinical features, and treatment. Dent Clin North Am 2013;57:583-96.
Katz J, Livneh A, Shemer J, et al. Herpes simplex-associated erythema multiforme (HAEM): a clinical therapeutic dilemma. Pediatr Dent 1999;21:359-62.
Lamoreux MR, Sternbach MR, Hsu WT. Erythema multiforme. Am Fam Physician 2006;74:1883-8.
Harr T, French LE. Toxic epidermal necrolysis and Stevens-Johnson syndrome. Orphanet J Rare Dis 2010;5:39. DOI: https://doi.org/10.1186/1750-1172-5-39
Hamblin MR. Photobiomodulation or low-level laser therapy. J Biophotonics 2016;9:1122-4. DOI: https://doi.org/10.1002/jbio.201670113
Mussttaf RA, Jenkins DFL, Jha AN. Assessing the impact of low-level laser therapy (LLLT) on biological systems: a review. Int J Radiat Biol 2019;95:120-43. DOI: https://doi.org/10.1080/09553002.2019.1524944
Khaleel Ahmed M, Jafer M, Nayeem M, et al. Low-Level Laser Therapy and Topical Medications for Treating Aphthous Ulcers: A Systematic Review. J Multidiscip Healthc 2020;13:1595-605. DOI: https://doi.org/10.2147/JMDH.S281495
Freitas LF, Hamblin MR. Proposed Mechanisms of Photobiomodulation or Low-Level Light Therapy. IEEE J Sel Top Quantum Electron 2016;22:7000417. DOI: https://doi.org/10.1109/JSTQE.2016.2561201
Huff JC, Weston WL, Tonnesen MG. Erythema multiforme: a critical review of characteristics, diagnostic criteria, and causes. J Am Acad Dermatol 1983;8:763-75. DOI: https://doi.org/10.1016/S0190-9622(83)80003-6
Sokumbi O, Wetter DA. Clinical features, diagnosis, and treatment of erythema multiforme: a review for the practicing dermatologist. Int J Dermatol 2012;51:889-902. DOI: https://doi.org/10.1111/j.1365-4632.2011.05348.x
Kokuba H, Aurelian L, Burnett J. Herpes simplex virus associated erythema multiforme (HAEM) is mechanistically distinct from drug-induced erythema multiforme: interferon-gamma is expressed in HAEM lesions and tumor necrosis factor-alpha in drug-induced erythema multiforme lesions. J Invest Dermatol 1999;113:808-15. DOI: https://doi.org/10.1046/j.1523-1747.1999.00754.x
Karu T. Is it time to consider photobiomodulation as a drug equivalent? Photomed Laser Surg 2013;31:189-91. DOI: https://doi.org/10.1089/pho.2013.3510
Karu TI, Pyatibrat LV, Afanasyeva NI. Cellular effects of low power laser therapy can be mediated by nitric oxide. Lasers Surg Med 2005;36:307-14. DOI: https://doi.org/10.1002/lsm.20148
Karu TI. Lasers in infertility treatment: irradiation of oocytes and spermatozoa. Photomed Laser Surg 2012;30:239-41. DOI: https://doi.org/10.1089/pho.2012.9888
Karu TI, Pyatibrat LV, Afanasyeva NI. A novel mitochondrial signaling pathway activated by visible-to-near infrared radiation. Photochem Photobiol 2004;80:366-72. DOI: https://doi.org/10.1111/j.1751-1097.2004.tb00097.x
Merigo E, Rocca JP, Pinheiro ALB, Fornaini C. Photobiomodulation Therapy in Oral Medicine: A Guide for the Practitioner with Focus on New Possible Protocols. Photobiomodul Photomed Laser Surg 2019;37:669-80. DOI: https://doi.org/10.1089/photob.2019.4624
Samim F, Auluck A, Zed C, Williams PM. Eritema multiforme: uma revisão da epidemiologia, patogênese, características clínicas e tratamento. Dent Clin North Am 2013;57:583-96. DOI: https://doi.org/10.1016/j.cden.2013.07.001
Wickenheisser VA, Zywot EM, Rabjohns EM, et al. Laser light therapy in inflammatory, musculoskeletal, and autoimmune disease. Curr Allergy Asthma Rep 2019;19:37. DOI: https://doi.org/10.1007/s11882-019-0869-z

How to Cite

Melo de Lima Morais, T., Silva, S. M. S. D. da, da Silva Peralta, F., Kitakawa, D., Saito Nogueira, M., & das Chagas e Silva de Carvalho, L. F. (2024). Low-level laser therapy as an adjuvant in the treatment of erythema multiforme of the oral mucosa: a case report. Laser Therapy, 31(1). https://doi.org/10.4081/ltj.2024.386

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