https://doi.org/10.4081/ltj.2023.325

Monitoring the effectiveness of nanosecond laser for the treatment of port-wine stain patients using non-invasive imaging systems

Vol. 30 No. 2 (2023)
Submitted: 6 September 2023
Accepted: 23 October 2023
Published: 16 November 2023
Laser therapy, port-wine stains, spectrophotometry, thermography
Abstract Views: 3541
PDF: 67
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Authors

Cheng-Han Jhan
https://orcid.org/0009-0006-0805-2069
Department of Surgery, Taipei Medical University Hospital, Taipei Medical University, Taiwan, Province of China.
Ana Elena Aviña
d142111012@tmu.edu.tw
https://orcid.org/0000-0001-6443-0200
International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taiwan; Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Taoyuan, Taiwan, Province of China.
Tzu-Sen Yang
https://orcid.org/0000-0003-0287-3916
Graduate Institute of Biomedical Optomechatronics, Taipei Medical University, Taiwan; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taiwan, Province of China.
Yu-Fan Chiang
Medical School, University of Queensland, Brisbane, Australia.
Cheng-Jen Chang
https://orcid.org/0000-0001-5481-581X
Graduate Institute of Biomedical Optomechatronics, Taipei Medical University, Taiwan; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taiwan;  Department of Plastic Surgery, Taipei Medical University Hospital, Taipei Medical University, Taiwan; School of Medicine, College of Medicine, Taipei Medical University, Taiwan; Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan, Province of China.

A variety of lasers have been used to treat port-wine stain (PWS) birthmarks, however, all of them carry the risk of adverse effects. Our objective was to assess the effectiveness and safety of nanosecond (ns) laser treatment for PWS patients using non-invasive images. This study included 20 PWS patients, whose ages ranged from one to sixteen years. A nanosecond laser (λ=595 nm; τp=2 ns), with a spot size of 5 mm, and parameters of 0.2-0.3 J/cm2, 5 Hz, was used in three passes. The infrared thermal imager aided in determining the optimal laser dosage and preventing side effects. The primary efficiency was evaluated using a DermaSpectrometer, and patients were followed up after one week, four weeks, three months, and twelve months. The infrared thermal images of skin surface temperature assessment in the first ten seconds were recorded after the maximal energy density 0.3 J/cm2 treatment. The thermal wave equation and Penne’s bioheat transfer equation ranged from 32.4±0.1 to 33.8±0.2°C, 32.6±0.1 to 34.7±0.3°C (baseline skin surface temperature - 32.4±0.3°C) respectively. Transient hyperpigmentation appeared in 5% (n=1) of the 20 patients, but it resolved spontaneously within three months. There was no evidence of permanent hypopigmentation or scarring. The DermaSpectrometer revealed a 30% reduction in Hb-index three months after a single treatment. The infrared image instrument is helpful in determining the optimum laser dosage. For the treatment of PWS patients, a nanosecond pulsed laser at 595nm was effective and safe.

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Cheng-Jen Chang, Graduate Institute of Biomedical Optomechatronics, Taipei Medical University, Taiwan; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taiwan;  Department of Plastic Surgery, Taipei Medical University Hospital, Taipei Medical University, Taiwan; School of Medicine, College of Medicine, Taipei Medical University, Taiwan; Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taipei

 

How to Cite

Jhan, C.-H., Aviña, A. E., Yang, T.-S., Chiang, Y.-F., & Chang, C.-J. (2023). Monitoring the effectiveness of nanosecond laser for the treatment of port-wine stain patients using non-invasive imaging systems. Laser Therapy, 30(2). https://doi.org/10.4081/ltj.2023.325
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