https://doi.org/10.4081/ltj.2024.398

Low-intensity laser-assisted antimicrobial photodynamic therapy and intravascular laser irradiation of blood in oncology: systematic review and a brief report

Vol. 31 No. 1 (2024)
Submitted: 18 March 2024
Accepted: 28 April 2024
Published: 14 May 2024
Cancer, laser therapy, low-intensity light therapy, intravascular laser irradiation of blood
Abstract Views: 1044
PDF: 156
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

Juliano Abreu Pacheco
Postgraduate Program, Ribeirão Preto College of Nursing, University of São Paulo; Research Coordinator, Ribeirão Preto Cancer Hospital, Sobeccan Hospital Foundation, Ribeirão Preto, Brazil.
Hermes Pretel
https://orcid.org/0000-0002-8077-1133
Collaborating Professor in the postgraduate program in Dental Sciences, São Paulo State University (UNESP), School of Dentistry, Araraquara, Brazil.
Sergio Luiz Pinheiro
https://orcid.org/0000-0001-7157-4923
Master’s Program in Health Sciences at Pontifical Catholic University of Campinas, Campinas, Brazil.
Kelly Fernanda Molena
kelly.molena@usp.br
Postgraduate Program in Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
Beatriz Tholt
Department of Restorative Dentistry, Almeida University; Laser Training Coordinator, São Leopoldo Mandic, Rio de Janeiro, Brazil.
Eugenia Velludo Veiga
Department of General and Specialized Nursing, School of Nursing of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.

Oncological patients may present with difficult-to-resolve oral lesions that impair their quality of life, and laser therapy can help these patients. This study sought to present a systematic review of the use of intravascular laser irradiation of blood (ILIB) and antimicrobial photodynamic therapy (aPDT) for oncological patients. Furthermore, it provides a brief report on a patient with laryngeal cancer who experienced cytotoxic symptoms such as oral mucositis and oral candidiasis while receiving aPDT and ILIB. A systematic search of PubMed, Scopus, Embase, Cochrane, Lilacs, Web of Science, Scielo, and Gray Literature was conducted, with no year or language restrictions, for primary clinical studies that used ILIB and aPDT to treat oral manifestations in oncological patients. In the brief report, aPDT was administered within the first five days, and ILIB was used for persistent lesions and pain. The review included five clinical studies. They included case reports, retrospective studies, randomized clinical trials, and non-randomized clinical trials. ILIB therapy combined with aPDT has been shown to reduce pain and promote faster healing when compared to not using ILIB. In our brief clinical case, healing was accelerated while pain and infectious inflammatory processes were reduced in the oral cavity. This neutralization of oral toxicity by combining aPDT and ILIB improved overall health, resulting in rapid healing of the oral lesions. The combination of aPDT and ILIB may be an effective therapy for the rapid recovery of oral lesions among cancer patients. More research is needed to better understand the effects of ILIB in oncology patients.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

Crossref
Scopus
Google Scholar
Europe PMC
Franco P, Martini S, Di Muzio J, et al. Prospective assessment of oral mucositis and its impact on quality of life and patient-reported outcomes during head and neck cancer radiotherapy. Med Oncol 2017;34:81. DOI: https://doi.org/10.1007/s12032-017-0950-1
Jain M, Shah R, Chandolia B, et al. The oral carriage of candida in oral cancer patients of Indian origin undergoing radiotherapy and chemotherapy. J Clin Diagn Res 2016;10:ZC17-ZC20. DOI: https://doi.org/10.7860/JCDR/2016/15702.7180
Lopes LD, Rodrigues AB, Brasil DRM, et al. Prevention and Treatment of Mucositis at an oncology outpatient clinic: a collective construction. Text and Context – Nursing 2016;25. DOI: https://doi.org/10.1590/0104-070720160002060014
Andrade RCDV, Reis TA, Rosa LP, et al. Comparative randomized trial study about the efficacy of photobiomodulation and curcumin antimicrobial photodynamic therapy as a coadjuvant treatment of oral mucositis in oncologic patients: antimicrobial, analgesic, and degree alteration effect. Support Care Cancer 2022;10.1007/s00520-022-07127-x.
Vila-Nova TEL, Leão RS, Santiago Junior JF, et al. Photodynamic therapy in the treatment of denture stomatitis: A systematic review and meta-analysis. J Prosthet Dent 2022;S0022-3913(21)00697-1.
Pacheco JA, Molena KF, Martins CROG, et al. Photobiomodulation (PBMT) and antimicrobial photodynamic therapy (aPDT) in oral manifestations of patients infected by Sars-CoV-2: systematic review and meta-analysis. Bull Natl Res Cent 2022;46:140. DOI: https://doi.org/10.1186/s42269-022-00830-z
Tavares A, Carvalho CM, Faustino MA, et al. Antimicrobial photodynamic therapy: study of bacterial recovery viability and potential development of resistance after treatment. Mar Drugs 2010;8:91-105. DOI: https://doi.org/10.3390/md8010091
Yang WH, Lin SP, Chang ST. Case report: Rapid improvement of crossed cerebellar diaschisis after intravascular laser irradiation of blood in a case of stroke. Medicine (Baltimore) 2017;96:e5646. DOI: https://doi.org/10.1097/MD.0000000000005646
Momenzadeh S, Abbasi M, Ebadifar A, et al. The intravenous laser blood irradiation in chronic pain and fibromyalgia. J Lasers Med Sci 2015;6:6-9.
Huang SF, Tsai YA, Wu SB, et al. Effects of intravascular laser irradiation of blood in mitochondria dysfunction and oxidative stress in adults with chronic spinal cord injury. Photomed Laser Surg 2012;30:579-86. DOI: https://doi.org/10.1089/pho.2012.3228
Pacheco JA, Schapochnik A, Sa CC. Successful Management of Dysgeusia byPhotobiomodulation (PBM) in a Cancer Patient. Med Case Rep J 2019;2:114. DOI: https://doi.org/10.31531/2581-5563.1000114
Pacheco JÁ, Silveira AM, Pretel H. Topical and systemic photobiomodulator treatment of lingual paresthesia caused by prolonge use of tamoxifen in a patient with breast cancer. EC Emerg Med Critical Care 2020:41-51.
Pacheco JA, Schapochnik A, Sá CC, et al. Applied transdérmic photobiomodulator therapy about the primary carotide artery in patients under hormonal blockers and dynude disorders and pathogenic flora of orofaringeo and systemic repercussions. Am J Biomed Sci Res 2019;4:813. DOI: https://doi.org/10.34297/AJBSR.2019.04.000813
Lima TO, Spin M, Lizarelli RFZ, et al. Transcutaneous laser therapy for hematopoietic adverse effects of antineoplastic chemotherapeutics: Randomized clinical trial. Nursing 2022;25:7834-40.
Silva LAD, Pinheiro SL. Clinical evaluation of intravascular blood irradiation with laser, photobiomodulation, and photodynamic therapy in cancer patients with mucositis. Photobiomodul Photomed Laser Surg 2021;39:687-95.
Shi Q, Mou C, Xie Z, Zheng M. Exploring BODIPY derivatives as photosensitizers for antibacterial photodynamic therapy. Photodiagnosis Photodyn Ther 2022;102901. DOI: https://doi.org/10.1016/j.pdpdt.2022.102901
Yin X, Fang Z, Fang Y, et al. Antimicrobial photodynamic therapy involving a novel photosensitizer combined with an antibiotic in the treatment of rabbit tibial osteomyelitis caused by drug-resistant bacteria. Front Microbiol 2022;13:876166. DOI: https://doi.org/10.3389/fmicb.2022.876166
Polat E, Kang K. Natural Photosensitizers in Antimicrobial Photodynamic Therapy. Biomedicines 2021;9:584. DOI: https://doi.org/10.3390/biomedicines9060584
Xu Y, Lin Y, Gao S. Study on the selection of laser wavelengths in the intravascular low-level laser irradiation therapy. Lasers Med Sci 2015;30:1373-6. DOI: https://doi.org/10.1007/s10103-015-1732-7
Silva LAD, Pinheiro SL. Clinical evaluation of intravascular blood irradiation with laser, photobiomodulation, and photodynamic therapy in cancer patients with mucositis. Photobiomodul Photomed Laser Surg 2021;39:687-95. DOI: https://doi.org/10.1089/photob.2021.0031
Lizarelli RFZ, Grecco C, Regalo SCH, et al. A pilot study on the effects of transcutaneous and transmucosal laser irradiation on blood pressure, glucose and cholesterol in women. Heliyon 2021;7:e07110. DOI: https://doi.org/10.1016/j.heliyon.2021.e07110
Zanin T, Zanin F, Carvalhosa AA, et al. Use of 660-nm diode laser in the prevention and treatment of human oral mucositis induced by radiotherapy and chemotherapy. Photomed Laser Surg 2010;28:233-7. DOI: https://doi.org/10.1089/pho.2008.2242
Mikhailov V. Development and clinical applications of intravenous laser blood irradiation (ILBI). Laser Ther 2009;18:69-83. DOI: https://doi.org/10.5978/islsm.18.69
Tomé RFF, Silva DFB, Dos Santos CAO, et al. ILIB (intravascular laser irradiation of blood) as an adjuvant therapy in the treatment of patients with chronic systemic diseases-an integrative literature review. Lasers Med Sci 2020;35:1899-907. DOI: https://doi.org/10.1007/s10103-020-03100-4
Pacheco JA, Molena KF, Veiga EV. Photobiomodulation for blood pressure and heart rate reduction in mastectomized women on hormone blockers: a randomized controlled trial. Photobiomodul Photomed Laser Surg 2024;42:294-305. DOI: https://doi.org/10.1089/photob.2023.0136

How to Cite

Pacheco, J. A., Pretel, H., Pinheiro, S. L., Molena, K. F., Tholt, B., & Veiga, E. V. (2024). Low-intensity laser-assisted antimicrobial photodynamic therapy and intravascular laser irradiation of blood in oncology: systematic review and a brief report. Laser Therapy, 31(1). https://doi.org/10.4081/ltj.2024.398
Copyright (c) 2024 the Author(s) Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.


Similar Articles

<< < 1 2 3 4 5 > >> 

You may also start an advanced similarity search for this article.